COVID reinfections: Overview of efficacy and duration of natural and hybrid immunity

“Natural immunity acquired after SARS-CoV-2 infections appears to be highly effective in terms of protection against reinfections and, more importantly, against COVID-19 serious outcomes. Efficacy seems to be equal or higher compared to individuals receiving two mRNA doses, but data are not fully consistent. Hybrid immunity, i.e. immunity achieved by SARS-CoV-2 infection plus vaccination, appears to be most protective.”

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COVID reinfections: Overview of efficacy and duration of natural and hybrid immunity

Researchers discover antibodies that neutralize omicron and other SARS-CoV-2 variants

“The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in the spike (S) protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness of available vaccines and antibody therapeutics…. The magnitude of Omicron-mediated immune evasion marks a major SARS-CoV-2 antigenic shift. Broadly neutralizing mAbs recognizing RBD epitopes conserved among SARS-CoV-2 variants and other sarbecoviruses may prove key to controlling the ongoing pandemic and future zoonotic spillovers.”

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Researchers discover antibodies that neutralize omicron and other SARS-CoV-2 variants

Protection and waning of natural and hybrid COVID-19 immunity

“Protection from reinfection decreases with time since previous infection, but is, nevertheless, higher than that conferred by vaccination with two doses at a similar time since the last immunity-conferring event. A single vaccine dose after infection helps to restore protection.”

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Protection and waning of natural and hybrid COVID-19 immunity