The Latest in COVID-19 Research

A collection of the best and most current COVID-19 research from medical journals and studies across the globe. 

Lactoferrin as potential preventative and adjunct treatment for COVID-19

NIH National Library of Medicine Raymond Chang, Tzi Bun Ng,and Wei-Zen Suna (July 30, 2020)

“Review the underlying biological mechanisms of Lf as an antiviral and immune regulator, and its unique potential as a preventative and adjunct treatment for COVID-19.”

Two common compounds show effectiveness against COVID-19 virus in early testing

UFHealth Doug Bennett (November 22, 2021)

“A pair of over-the-counter compounds has been found in preliminary tests to inhibit the virus that causes COVID-19, University of Florida Health researchers have found.”

150 Research Studies Affirm Naturally Acquired Immunity to Covid-19: Documented, Linked & Quoted

Brownstone Institute Paul Elias Alexander (FEBRUARY 8, 2022)

“The most update-to-date and comprehensive list of the highest-quality, complete, most robust scientific studies and evidence reports/position statements on natural immunity contrasted with vaccine-induced immunity (150 and counting).”

COVID reinfections: Overview of efficacy and duration of natural and hybrid immunity

NCBI PubMed Central (FEBRUARY 08, 2022)

“Natural immunity acquired after SARS-CoV-2 infections appears to be highly effective in terms of protection against reinfections and, more importantly, against COVID-19 serious outcomes. Efficacy seems to be equal or higher compared to individuals receiving two mRNA doses, but data are not fully consistent. Hybrid immunity, i.e. immunity achieved by SARS-CoV-2 infection plus vaccination, appears to be most protective.”

Researchers discover antibodies that neutralize omicron and other SARS-CoV-2 variants

medRxiv Preprint (DECEMBER 23, 2021)

“The recently emerged SARS-CoV-2 Omicron variant encodes 37 amino acid substitutions in the spike (S) protein, 15 of which are in the receptor-binding domain (RBD), thereby raising concerns about the effectiveness of available vaccines and antibody therapeutics…. The magnitude of Omicron-mediated immune evasion marks a major SARS-CoV-2 antigenic shift. Broadly neutralizing mAbs recognizing RBD epitopes conserved among SARS-CoV-2 variants and other sarbecoviruses may prove key to controlling the ongoing pandemic and future zoonotic spillovers.”

Protection and waning of natural and hybrid COVID-19 immunity

medRxiv Preprint (DECEMBER 5, 2021)

“Protection from reinfection decreases with time since previous infection, but is, nevertheless, higher than that conferred by vaccination with two doses at a similar time since the last immunity-conferring event. A single vaccine dose after infection helps to restore protection.”

WHO international standard for SARS-CoV-2 antibodies to determine markers of protection

THE LANCET Microbe. (October 26, 2021)

“One of the important elements of regulatory evaluation is the measurement of the vaccine-induced immune response, for which guidance is available in the WHO guidelines on the clinical evaluation of vaccines. Evaluation of the immunogenicity of a vaccine aims to identify a possible correlate of protection. Although it is still unclear what such a correlate could be for SARS-CoV-2, neutralising or binding antibodies are good candidates. However, identification of a correlate of protection requires the comparison of immunological data from different clinical trials, but is often confounded by the differences in assays, target antigens, numerical readouts, and endpoints.”

Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice

Military Medical Research volume 8, Article number: 47 (AUGUST 31, 2021)

“We summarise the onset and persistence of IgA, IgM and IgG antibodies, and we explore their roles in neutralising SARS-CoV-2, their persistence in convalescent individuals, and in reinfection. Furthermore, we also review the applications of neutralising antibodies in the clinical setting—from predictors of disease severity to serological testing to vaccinations, and finally in therapeutics such as convalescent plasma infusion.”

Covid-19 Breakthrough Infections in Vaccinated Health Care Workers

The NEW ENGLAND JOURNAL of MEDICINE (JULY 28, 2021)

“Among fully vaccinated health care workers, the occurrence of breakthrough infections with SARS-CoV-2 was correlated with neutralizing antibody titers during the peri-infection period. Most breakthrough infections were mild or asymptomatic, although persistent symptoms did occur.”